Category: 1060814-53-0

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These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (5-Chloropyrazin-2-yl)methanamine, its application will become more common.

Synthetic Route of 1060814-53-0,Some common heterocyclic compound, 1060814-53-0, name is (5-Chloropyrazin-2-yl)methanamine, molecular formula is C5H6ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2544-N-[(5-chloropyrazin-2-yl)methyl]-6-(2, 3-di methyl phenyl)pyri midine-2,4-diam me.4-Chloro-6-(2,3-dimethylphenyl)pyrimidin-2-amine (12 mg, 0,050 mmol), (5- chloropyrazin-2-yl)methanamine (14 mg, 0,10 mmol), Et3N (0,040 mL, 0,30 mmol) and 1-butanol (0,20 mL) were stirred at 100C for 20 hours. MeOH (1 mL) was added and the mixture was purified by preparative HPLC to give the desiredproduct. LCMS [M+H] 341.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (5-Chloropyrazin-2-yl)methanamine, its application will become more common.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; HELLEDAY, Thomas; KOOLMEISTER, Tobias; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; WO2014/84778; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The important role of (5-Chloropyrazin-2-yl)methanamine

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 1060814-53-0, A common heterocyclic compound, 1060814-53-0, name is (5-Chloropyrazin-2-yl)methanamine, molecular formula is C5H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 254 4-N-[(5-chloropyrazin-2-yl)methyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine. 4-Chloro-6-(2,3-dimethylphenyl)pyrimidin-2-amine (12 mg, 0,050 mmol), (5- chloropyrazin-2-yl)methanamine (14 mg, 0, 10 mmol), Et3N (0,040 mL, 0,30 mmol) and 1-butanol (0,20 mL) were stirred at 100C for 20 hours. MeOH (1 mL) was added and the mixture was purified by preparative HPLC to give the desired product. LCMS [M+H]+ 341.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.