Category: 1049026-49-4

Adding a certain compound to certain chemical reactions, such as: 1049026-49-4, name is 2-Bromo-5-(methylthio)pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1049026-49-4, Quality Control of 2-Bromo-5-(methylthio)pyrazine

(107d) 2-Bromo-5-(methylsulfonyl)pyrazine 2,5-Dibromopyrazine (270 mg, 1.14 mmol) was dissolved in tetrahydrofuran (10 mL), and sodium thiomethoxide (320 mg, 4.57 mmol) was added at room temperature, followed by stirring at room temperature for 2.5 hours under nitrogen atmosphere. To this reaction solution, water (10 mL) was added, and extraction was carried out with diethyl ether (10 mL). The organic layer was washed with saturated brine, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=5%-10%) to afford a yellow solid. This was dissolved in methylene chloride (10 mL), and m-chloroperbenzoic acid (approximately 65%, 580 mg, approximately 2.2 mmol) was added at room temperature, followed by stirring at room temperature for 1 hour under nitrogen atmosphere. To this reaction solution, a saturated aqueous sodium hydrogencarbonate solution (10 mL) was added, and extraction was carried out with methylene chloride (10 mL). The organic layer was washed with saturated brine, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=15%-25%) to afford the desired compound (190 mg, yield 70%) as a white solid. 1H-NMR (CDCl3, 400 MHz): delta 3.26 (3H, s), 8.80 (1H, d, J=1.2 Hz), 9.06 (1H, d, J=1.2 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-(methylthio)pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP2239253; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 1049026-49-4, These common heterocyclic compound, 1049026-49-4, name is 2-Bromo-5-(methylthio)pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: To a solution of 2-bromo-5-(methylthio)pyrazine (CAS1049026-49-4, 5 g) in (0432) N,N-dimethylacetamide (10 ml) were added ethane- 1,2-diol (7.57 g) and potassium carbonate (5.05 g). The mixture was stirred at room temperature for 18 h. The mixture was heated to 60 C for 8 h and stirred at room temperature for 3 days. The mixture was heated to 90 C for 1.5 h. The temperature was raised to 100 C and the mixture was stirred for 2 h. After cooling to room temperature, water was added and the mixture was extracted with EtOAc. The organic layers were dried (MgS04), filtered and concentrated in vacuo.The crude material was purified by flash chromatography (Si02, 0% to 50% EtOAc in n-heptane) to give 2-((5-(methylthio)pyrazin-2- yl)oxy)ethanol (2.88 g) as colorless solid. MS: m/z = 187.1 [M+H]+.

Statistics shows that 2-Bromo-5-(methylthio)pyrazine is playing an increasingly important role. we look forward to future research findings about 1049026-49-4.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; SIENA BIOTECH S.P.A.; GUBA, Wolfgang; HAAP, Wolfgang; OBST SANDER, Ulrike; PETERS, Jens-Uwe; WOLTERING, Thomas; (81 pag.)WO2016/1266; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 1049026-49-4, A common heterocyclic compound, 1049026-49-4, name is 2-Bromo-5-(methylthio)pyrazine, molecular formula is C5H5BrN2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B: 2-bromo-5-(methylsulfonyl)pyrazine: An aqueous solution of Oxone (4.0 g, 6.6 mmol,3.13 mL) was added dropwise to a methanol solution of 2-bromo-5-(methylsulfanyl)pyrazine(450 mg, 2.2 mmol, 19 mL) at ambient temperature. The reaction mixture was stirred for 3hours, filtered over a pad of CELITE and then organic layer was concentrated in vacuo. The crude residue was purified via MPLC (0-100% EtOAc/hexane gradient) to afford titlecompound.

The synthetic route of 1049026-49-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1049026-49-4, name is 2-Bromo-5-(methylthio)pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1049026-49-4, Safety of 2-Bromo-5-(methylthio)pyrazine

(107d) 2-Bromo-5-(methylsulfonyl)pyrazine 2,5-Dibromopyrazine (270 mg, 1.14 mmol) was dissolved in tetrahydrofuran (10 mL), and sodium thiomethoxide (320 mg, 4.57 mmol) was added at room temperature, followed by stirring at room temperature for 2.5 hours under nitrogen atmosphere. To this reaction solution, water (10 mL) was added, and extraction was carried out with diethyl ether (10 mL). The organic layer was washed with saturated brine, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=5%-10%) to afford a yellow solid. This was dissolved in methylene chloride (10 mL), and m-chloroperbenzoic acid (approximately 65%, 580 mg, approximately 2.2 mmol) was added at room temperature, followed by stirring at room temperature for 1 hour under nitrogen atmosphere. To this reaction solution, a saturated aqueous sodium hydrogencarbonate solution (10 mL) was added, and extraction was carried out with methylene chloride (10 mL). The organic layer was washed with saturated brine, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=15%-25%) to afford the desired compound (190 mg, yield 70%) as a white solid. 1H-NMR (CDCl3, 400 MHz): delta 3.26 (3H, s), 8.80 (1H, d, J=1.2 Hz), 9.06 (1H, d, J=1.2 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-(methylthio)pyrazine, other downstream synthetic routes, hurry up and to see.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine. In a document, author is Dagar, Anuradha, introducing its new discovery. Computed Properties of C5H5BrN2S.

Solvent-Controlled Divergent Syntheses of PolycyclicN-Fused Heteroaromatics

Due to a growing interest in aza-fused polyaromatic systems among various sciences, enormous attention has been continuously paid to design and synthesize novel chemotypes of N-fused hetero-cycles. During the course of continued efforts in this line, it was found that divergent access to new polycyclic N-fused heteroaromatics was enabled by choice of reaction solvent. Described herein are solvent-controlled selective approaches to three novel N-fused azacycles, benzo-[d]imidazole-pyrrolo[1,2-a]pyrazine hybrids, under mild conditions. The plausible reaction mechanism for each class of compound is suggested as well.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1049026-49-4 help many people in the next few years. Computed Properties of C5H5BrN2S.

1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, molecular formula is C5H5BrN2S, belongs to Pyrazines compound, is a common compound. In a patnet, author is Wu, Haozhong, once mentioned the new application about 1049026-49-4, Recommanded Product: 1049026-49-4.

Each phenyl group performs its own functions on luminescence: phenyl substituted effect in tetraphenylpyrazine

Aggregation-induced emission (AIE) has drawn considerable attention owing to its interesting phenomenon, and the AIE mechanisms of different molecule systems have been gradually revealed. Here, we investigated the difference in 3-carbazole-pyrazine-based isomers and explored the effects of three substituted phenyl groups (ortho, meta and para) on the tetraphenylpyrazine derivatives (TPPs). The meta- and para-phenyl groups could slightly and significantly adjust their emission properties, respectively. The ortho-phenyl group could distort the pyrazine plane owing to the large steric hinderance of the two moieties; this triggered many molecular motions and led to the wastage of excited state energy, stimulating the AIE characteristics of TPPs. This result is demonstrated for other pyrazine derivatives and can serve as a design strategy of AIE molecules.

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Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, SMILES is CSC1=CN=C(Br)C=N1, belongs to Pyrazines compound. In a document, author is Gao, Ruichang, introduce the new discover, HPLC of Formula: C5H5BrN2S.

Screening of a Planococcus bacterium producing a cold-adapted protease and its application in low-salt fish sauce fermentation

A strain of bacteria isolated from a traditional fermented shrimp paste showed high protease activity at low-temperature (15 degrees C). The strain was identified asPlanococcus maritimusand namedPlanococcus maritimusXJ2.P. maritimusXJ2 grows well in a low-temperature, low-salt, and alkaline environment. The protease produced byP. maritimusXJ2 exhibited the highest enzyme activity at 40 degrees C, pH 9.0 and showed salt tolerance. The amino acid nitrogen content of low-salt fish sauce inoculated withP. maritimusXJ2 was 1.28 +/- 0.04 g/100 ml, which was significantly higher than that of the control withoutP. maritimusXJ2 (0.89 +/- 0.02 g/100 ml,p < .01). The amounts of key desirable volatiles, such as alcohols, ketones, acids, esters, and pyrazine were higher inP. maritimusXJ2 than in the control (p < .05).P. maritimusXJ2 could be used as a starter culture for low-salt fish sauce incubated at 21 degrees C. Practical applications The bacteria identified in this study has a good capacity to ferment the fish for good quality of fish sauce. A new method for the rapid fermentation of low-salt fish sauce and the improvement of its flavor by usingPlanococcus maritimusXJ2 is established. The procedure can help people to produce fish sauce in a shorter time, which will promote the development of fish sauce industry. Therefore, the starter and the method have good practical application in fish sauce produce. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1049026-49-4 is helpful to your research. HPLC of Formula: C5H5BrN2S.

Related Products of 1049026-49-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, SMILES is CSC1=CN=C(Br)C=N1, belongs to Pyrazines compound. In a article, author is Meng, Ling, introduce new discover of the category.

Nanographene – rhenium complex as efficient catalyst for electrochemical reduction: A computational study

A complete mechanism for electrocatalytic reduction of CO2 to CO by nanographene – rhenium complex (Re (gpy-bpy)(CO)(3)Cl, gpy = nanographene connected with pyrazine; bpy = 2,2′-bipyridyl) was investigated by using density functional theory (DFT) calculations. The reaction free energies, reaction barrier heights, charge decomposition analysis (CDA), spin densities and mulliken populations provide deep insight into the reaction mechanism as well as the origin of selectivity for this catalyst. Protonation and then reduction of Re(gpy-bpy) (CO)(3)COOH (Re-COOH) precedes Bronsted-acid-catalyzed C – OH bond cleavage and then CO release at external applied potential. It is expected that the present work would provide valuable information for designing catalyst.

Related Products of 1049026-49-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1049026-49-4.

Application of 1049026-49-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, SMILES is CSC1=CN=C(Br)C=N1, belongs to Pyrazines compound. In a article, author is Song, Xuebo, introduce new discover of the category.

Untargeted and targeted metabolomics strategy for the classification of strong aroma-type baijiu (liquor) according to geographical origin using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry

A metabolomics strategy was developed to differentiate strong aroma-type baijiu (SAB) (distilled liquor) from the Sichuan basin (SCB) and Yangtze-Huaihe River Basin (YHRB) through liquid-liquid extraction coupled with GCxGC-TOFMS. PCA effectively separated the samples from these two regions. The PLS-DA training model was excellent, with explained variation and predictive capability values of 0.988 and 0.982, respectively. As a result, the model demonstrated its ability to perfectly differentiate all the unknown SAB samples. Twenty-nine potential markers were located by variable importance in projection values, and twenty-four of them were identified and quantitated. Discrimination ability is closely correlated to the characteristic flavor compounds, such as acid, esters, furans, alcohols, sulfides and pyrazine. Most of the marker compounds were less abundant in the SCB samples than in the YHRB samples. The quantitated markers were further processed using hierarchical cluster analysis for targeted analysis, indicating that the markers had great discrimination power to differentiate the SAB samples.

Application of 1049026-49-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1049026-49-4 is helpful to your research.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, formurla is C5H5BrN2S. In a document, author is Metwally, Nadia H., introducing its new discovery. Computed Properties of C5H5BrN2S.

Crystal structure of ethyl 2-(5-amino-1-benzene-sulfonyl-3-oxo-2,3-dihydro-1H-pyrazol-2-yl)acetate

In the title compound, C13H15N3O5S, the two rings face each other in a ‘V’ form at the S atom, with one N-H center dot center dot center dot O=S and one C-H center dot center dot center dot O=S contact from the pyrazolyl substituents to the sulfonyl group. Two classical hydrogen bonds from the amine group, one of the form N-H center dot center dot center dot O=S and one N-H center dot center dot center dot O Coxo, link the molecules to form layers parallel to the bc plane.

If you are hungry for even more, make sure to check my other article about 1049026-49-4, Computed Properties of C5H5BrN2S.