Author: Jessica.F

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 33332-25-1, Name is Methyl 5-chloropyrazine-2-carboxylate, SMILES is ClC1=CN=C(C=N1)C(=O)OC, in an article , author is Sorkhi, Seyyed Erfan Sadati, once mentioned of 33332-25-1, Computed Properties of C6H5ClN2O2.

Introduction of a novel dicationic Bronsted acidic ionic liquid based on pyrazine and its application in the synthesis of xanthenediones and 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

A novel dicationic Bronsted acidic ionic liquid based on pyrazine has been prepared and characterized by FTIR, H-1 NMR, C-13 NMR, MS, thermal gravimetric and differential thermal gravimetric analysis and also Hammett acidity function. The prepared dicationic ionic liquid is found to be an efficient and reusable catalyst for the synthesis of xanthenediones and 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions. The merits of the developed procedure include novelty in terms of the ionic liquid, easy preparation of the ionic liquid, easy workup, reusability of the catalyst, high yield, short reaction time and absence of toxic organic solvent.

Interested yet? Read on for other articles about 33332-25-1, you can contact me at any time and look forward to more communication. Computed Properties of C6H5ClN2O2.

Reference of 20737-42-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a article, author is Xu, Zhen, introduce new discover of the category.

Color tuning for black-to-transmissive conjugated copolymer with excellent electrochromic properties via electrochemical copolymerization of two donor-acceptor type monomers

Copolymerization towards producing broadly absorbing black neutrality for flexible electrochromics was investigated. Neutral-state saturated green and dark blue donor-acceptor-donor (D-A-D) polymers consisting of electron-acceptor thieno[3,4-b]pyrazine and benzo[1,2,3]triazole based units respectively, were chosen as distributed segments, simultaneous with their tendency to switch to transmissive oxidation states. Variation of the feed ratio of two precursors in a mixture solution was used to regulate the energy and spectral absorption range of electrochemical copolymerization films. Co-polymer PEM-11 in 1:1 monomer feed ratio demonstrated a full range of visible absorption, and switched between an improved saturated black neutral state (L* = 43.68, a* = 4.98, b* = -13.13) and a light gray transmissive oxidation state (L* = 67.30, a* = -1.36, b* = 1.67) reversibly, where L* represents white to black balance, a* red to green and b* yellow to blue, with the optical contrast of 35% at 590 nm and switching speed as low as 0.6 s. Furthermore, the PEM-11 film exhibited stable n-doping, favorable cycle stability, and a lower electrochemical/optical band-gap (0.80 eV/1.21 eV) in comparison with the reported individual neutral black ECPs. The results suggested that the as-obtained copolymer could be a promising candidate for electrochromic windows, e-papers, or eyewear applications. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Reference of 20737-42-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 20737-42-2 is helpful to your research.

Reference of 290-37-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 290-37-9, Name is Pyrazine, SMILES is C1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Wang, Cheng, introduce new discover of the category.

Design and optimization of orally spleen tyrosine kinase (SYK) inhibitors for treatment of solid tumor

As the aim to discover orally SYK inhibitors for solid tumor treatment, a series of novel derivatives based on imidazo[1,2-a]pyrazine scaffold were designed, synthesized and evaluated. Structure-activity relationship study of both enzymatic and cellular assays led to the identification of compound 12f. The novel SYK inhibitor 12f showed potent antitumor activity against solid tumors with favorable drug-like properties of lipophilicity and solubility. 12f could induce cell apoptosis of ovarian and lung cancer cell lines. In SKOV3 xenograft mouse model, oral administration of 12f led to significant tumour regression without obvious toxicity. 12f improved the limited response of traditional SYK inhibitors in solid tumors in vitro and in vivo. Taken together, this compound may act as a promising lead compound for further development of new SYK inhibitors for solid tumor therapy.

Reference of 290-37-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 290-37-9 is helpful to your research.

In an article, author is Ojha, Minita, once mentioned the application of 14508-49-7, Name is 2-Chloropyrazine, molecular formula is C4H3ClN2, molecular weight is 114.53, MDL number is MFCD00006124, category is Pyrazines. Now introduce a scientific discovery about this category, Name: 2-Chloropyrazine.

Generation and trapping of non-aromatic cycloimines via diazotization/dediazotization of N-amino cyclic amines: theoretical and experimental results

A theoretical investigation of the model diazotization/dediazotization of N-aminopiperidine and N-aminomorpholine at the DFT (B3LYP/6-31+G(d)) level indicated that the corresponding cycloimines can be generated transiently, which can be trapped with dimethyl acetylenedicarboxylate (DMAD) to form a 1,4-dipole followed by cycloaddition of the latter with a second molecule of DMAD to give the corresponding pyrido-annelated products. All steps have low activation free energy barriers and are thermodynamically favoured. Based on the theoretical results, we carried out successfully diazotization of N-amino cyclic amines, namely N-aminopiperidine, 4-aminomorpholine and 1-amino-4-methylpiperazine withtert.-butyl nitrite followed by dediazotization to generate transiently the corresponding cycloimines, which could be trapped with dimethyl acetylenedicarboxylate. to afford new annelated pyridine derivatives, namely tetramethyl9H-5,6,7,8-tetrahydroquinolizine-1,2,3,4-tetracarboxylate, tetramethyl 5,6,8,9-tetrahydropyrido[2,1-c][1,4]oxazine-1,2,3,4-tetracarboxylate and tetramethyl9H-5,6,7,8-tetrahydro-7-methylpyrido[1,2-a]pyrazine-1,2,3,4-tetracarboxylate which were duly characterized.

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Reference of 19847-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Zhou, Jiadi, introduce new discover of the category.

delta-Regioselective heteroarylation of free alcohols through 1,5-hydrogen-atom transfer

An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed. Various alcohols reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp(2))-H alkylation products in 31-89% yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of d-C(sp(3))-H bonds in the alcohols could be regioselectively activated. This protocol provides a platform to access divergent functionalizations of alcohols and heteroaryls by forming the challenging d-selective C(sp(3))-C(sp(2)) bond.

Reference of 19847-12-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19847-12-2.

Reference of 33332-25-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 33332-25-1, Name is Methyl 5-chloropyrazine-2-carboxylate, SMILES is ClC1=CN=C(C=N1)C(=O)OC, belongs to Pyrazines compound. In a article, author is Benecke, Jannik, introduce new discover of the category.

A Flexible and Porous Ferrocene-Based Gallium MOF with MIL-53 Architecture

A new gallium based metal-organic framework, denoted as Ga-MIL-53-FcDC, with the chemical formula [Ga(OH)(FeC12H8O4)] was synthesized using the ferrocene containing linker molecule 1,1′-ferrocenedicarboxylic acid (H(2)FcDC, FeC12H10O4). The porous nature of the compound could be confirmed by nitrogen sorption and a specific surface area of 270 m(2)/g was determined. The persistence of the ferrocene complex inside the structure was confirmed by Mossbauer-, EPR and UV/VIS-spectroscopy. Ga-MIL-53-FcDC shows structural flexibility depending on which guest molecule is located in the pores of the compound. The mechanism of structural flexibility was analyzed by means of powder X-ray diffraction adsorbing pyrazine or iodine. The flexibility of the crystal structure can be attributed to the torsion of the GaO6 octahedra in the IBU respective to each other and the torsion of the carboxylate groups of FcDC(2-) relative to the aromatic ring.

Reference of 33332-25-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 33332-25-1 is helpful to your research.

Electric Literature of 19847-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Gawad, Jineetkumar, introduce new discover of the category.

Design, synthesis and biological evaluation of novel 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives as a potential DprE1 inhibitors

In a search of new potentially active antitubercular agents, here we have initiated with pharmacophore development, virtual screening and molecular docking studies to know flexible binding modes with target cavity of DprE1 enzyme. We have designed and synthesized 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives and evaluated for antitubercular activity with specific DprE1 inhibition. The various steps have been completed by performing conden-sation of 6-(trifluoromethyl)quinazoline-2-carboxylic acid, aromatic aldehydes, methanol, Hydrazine hydrate,-(trifluoromethyl)quinazoline-2-carbohydrazide, 6-(trifluoromethyl)-N’-methylenequinazoline-2-carbohydrazide to obtained 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives (3a-r) in better yields. Synthesized derivatives were characterized for their spectral anal-ysis. These compounds have been screened for their in vitro antitubercular activity against Mycobacte-rium tuberculosis H 37 RV. The compounds 3a (MIC-1.27 m M); 3e (MIC-1.12 m M); 3p (MIC-1.18 m M); and 3r (MIC-0.96 m M); exhibited notable in vitro antitubercular activity compare to the reference standard, Isoniazid. These four compounds were screened for DprE1 enzyme assay. Among those 3e and 3r has shown strong DprE1 inhibition, these compounds were substituted with nitro and hydroxyl group. (c) 2020 Elsevier B.V. All rights reserved.

Electric Literature of 19847-12-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19847-12-2.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2. In an article, author is Karmakar, Ananta,once mentioned of 123-32-0, SDS of cas: 123-32-0.

Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a ]pyrazines from alpha-Aminoacetonitriles

An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2- a ]pyrazine derivatives is described that originates from alpha-substituted pyrroloacetonitriles which, in turn, are readily available from aryl and alkyl aldehydes. The alpha-pyrroloacetonitriles were subjected to a Friedel-Crafts acylation with methyl chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2- a ]pyrazine derivatives. This method was generalized and successfully applied to various aryl, heteroaryl, and alkyl substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51-68%) without the need for purification of the intermediates. Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into benzoxazole derivatives.

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Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C5H4N2O3, 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a document, author is Kirkman-Davis, Emma, introduce the new discover.

Pyrazine-bridged Cu(II) chains: diaquabis(n-methyl-2-pyridone)copper(II) perchlorate complexes

A family of pyrazine-bridged, linear chain complexes of Cu(II) of the formula [CuL2(H2O)(2)(pz)](ClO4)(2) [pz = pyrazine; L = n-methyl-2(1H)-pyridone, n = 3 (1), 5 (2), and 6 (3)] has been prepared. Single-crystal X-ray diffraction shows six-coordinate, pyrazine-bridged chains with trans-pairs of ancillary ligands. The substituted pyridine molecules exist in their pyridone tautomers and are coordinated through the carbonyl oxygen atom. The structure is stabilized by intramolecular hydrogen bonds between the pyridone and water molecule, and via hydrogen bonds between the water molecules and perchlorate ions. 2 undergoes a crystallographic phase transition between C2/c (high temperature phase) and P (1) over bar (low temperature phase). Powder EPR spectra reveal that all complexes are rhombic, although differences between g(x) and g(y) can only be seen clearly at Q-band. Variable temperature magnetic susceptibility data show antiferromagnetic interactions and the data were fit to the uniform chain model yielding J/k(B) = -9.8, -9.2 and -11 K for 1-3 respectively. Attempts to model an interchain interaction strength indicate that the chains are very well isolated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20737-42-2 is helpful to your research. Computed Properties of C5H4N2O3.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, molecular formula is , belongs to Pyrazines compound. In a document, author is Zhang, Dan, Formula: C5H5BrN2S.

Synthesis, crystal structures, fluorescence, and magnetic properties of 1,3,5-benzenetricarboxylate coordination polymers

Four new coordination polymers, {[Mn-3(BTC)(2)(4-pp)(6)(H2O)(2)]center dot(4-pp)(2)(H2O)(2)}(n) 1, [Cu-3(BTC)(2)(dpa)(2)](n) 2, {[Zn-3(BTC)(2)(4-pp)(6)]center dot(H2O)}(n) 3, and [Ag-2(HBTC)(Pz)(1/2)](n) 4, were synthesized under pH-controlled solvothermal conditions with symmetrical polycarboxylic acid of 1,3,5-benzenetricarboxylic acid (H3BTC) and nitrogen-containing heterocyclic compounds, pyrazine (pz), 4-phenylpyridine (4-pp), and 4,4 ‘-dipyridylamine (dpa). Complexes 1-4 were characterized by single-crystal X-ray diffraction, elemental analysis, IR spectra, powder X-ray diffraction, thermal gravimetric analysis, photoluminescence, and magnetic susceptibility. Complexes 1 and 3 show two-dimensional (2-D) layered structures, 2 exhibits a three-dimensional (3-D) network structure, and 4 is a one-dimensional (1-D) polymeric chain structure. Magnetic susceptibility measurements indicate that 1 shows weak antiferromagnetic coupling between Mn-II ions and 2 exhibits ferromagnetic interaction between Cu-II ions. The photoluminescence properties of 3 and 4 are similar to the ligand H3BTC.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1049026-49-4, in my other articles. Formula: C5H5BrN2S.