Author: Freya.E

Related Products of 33332-25-1, These common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

delta-chloro-pyrazine^-carboxylic acid methyl ester (10.02g, 58.25mmol) and hydrazine monohydrate(12.5mL, 250mmol) were dissolved in methanol (40OmL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title compound, 5.01 g (50%).1H NMR(CDCI3, 400MHz) delta: 4.09(d, 2H), 8.52(s, 1 H), 8.66(bs, 1 H), 9.14(s, 1 H). Microanalysis:C5H5CIN4O requires: C 34.80; H” 2.92; N 32.47; found C 34.89; H 2.91 , N 32.32. MS APCI+ m/z 173[MH]+

The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109838-85-9, Application In Synthesis of (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Step B – Synthesis of Intermediate Compound Int-8d (i?)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (Int-8c, 25 g, 135.7 mmol) and dried THF (500 mL) were added to a dried 1 -liter flask which was cooled to -78 °C and maintained under nitrogen atmosphere. A solution of 2.5 M n-BuLi in hexane (54 mL, 135 mmol) was added slowly via a syringe. The resulting solution was allowed to stir at the cold temperature for 30 min before addition of Int-8b (90.5 g, 266.2 mmol) via a syringe. The reaction mixture was continued to stir for 4 hours and warmed to room temperature gradually over a period of 1 hour. After addition of water (100 mL) and diethyl ether (1.0 liter), the solution was washed with water (2 x 200 mL) and dried over sodium sulfate. The solution was concentrated and the residue obtained was purified using a 330 g ISCO silica column on Combi-Flash with 0-1percent ether in hexanes as an eluent to provide Int-8d as an oil (18.5 g, 35percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 15707-23-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15707-23-0, name is 2-Ethyl-3-methylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 1000 ml three-necked flask, 30.0 g of 2-ethyl-3-methylpyrazine (content 99%), 0.82 g of ferric chloride (n/n: 50:1),0.92 g of 1,10-phenanthroline (n/n: 50:1), 14.8 g of propionic acid and 145 g of t-butanol peroxide, stirred with a magnetic stirrer,The mixture was heated to an internal temperature of 65 to 75 C, and the reaction was terminated after 24 hours, and distilled under reduced pressure to obtain 2-acetyl-3-methylpyrazine.The conversion of 2-ethyl-3-methylpyrazine was 48.75%, and the selectivity of 2-acetyl-3-methylpyrazine was 95.88%.

The synthetic route of 2-Ethyl-3-methylpyrazine has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 108-50-9, name is 2,6-Dimethylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H8N2

EXAMPLE 29 2-Sulfonylmethyl-6-methylpyrazine sodium salt (2900) A mixture of 5.4 g of 2,6-dimethylpyrazine and 8.9 g of N-bromosuccinimide in 200 ml of carbon tetrachloride was heated to 75 and 6.1 g of dibenzoyl peroxide added. It was refluxed 6 hours, cooled, filtered and the filtrate concentrated. To this concentrate was added 10 g sodium sulfite/100 ml water and the mixture refluxed for 4 days. This aqueous solution was then continuously extracted overnight with chloroform, freeze-dried and the resultant solid taken up in 250 ml of methanol. It was filtered, the filtrate concentrated and chromatographed (Biogel P-2/water) to give 4.8 g of product (2900). It was recrystallized from ethanol/water, m.p. 282-5 (dec.). UV H2 O max: 208 (3.80), 276 (3.88).

The synthetic route of 2,6-Dimethylpyrazine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., Quality Control of 3,5-Dibromo-1-methylpyrazin-2(1H)-one

A 100-mL three-neck round-bottomed flask equipped with a reflux condenser, magnetic stirrer and nitrogen inlet was charged with 116b (400 mg, 1.66 mmol), 3,5- dibromo-1 -methyl pyrazin-2(lH)-one (443 mg, 1.66 mmol), cesium carbonate (1.19 g, 3.65 mmol), and 1,4-dioxane (20 mL). After bubbling nitrogen through the resulting suspension for 30 min, Xantphos (144 mg, 0.249 mmol) and tris(dibenzylideneacetone)-dipalladium(0) (152 mg, 0.166 mmol) were added, and the reaction mixture was heated at reflux for 4 h. After this time, the mixture was cooled to room temperature and filtered, and the filter cake was washed with methylene chloride (2 x 20 mL). The filtrates were combined and concentrated under reduced pressure, and the resulting residue was purified by column chromatography to afford a 51percent yield (353 mg) of 116c as a yellow solid: mp 172-173 °C; ]H NMR (500 MHz, CDC13) delta 8.17 (s, 1H), 8.06 (s, 1H), 7.65 (s, 1H), 6.70 (s, 1H), 4.28 (t, 2H, / = 5.0 Hz), 3.97 (t, 2H, / = 5.5 Hz), 3.51 (s, 3H), 0.85 (s, 9H), -0.79 (s, 6H); MS (APCI+) m/z 428.3 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 21279-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 21279-62-9 name is 3-Chloropyrazine-2-carboxamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The starting compound (1.27 mmol) was treated with 18 aliphatic amines, alicyclic amines or saturated heterocycles containing at least one nitrogen atom (2.54 mmol). Four reactions were completed by conventional heating methods. The conditions were 110 C, toluene as a solvent and pyridine (1.27 mmol) as a base. The reaction time was set to one hour. Then the reactions were completed using the microwave reactor with focused field and conditions used for syntheses were 140 C, 30 min,120 W, methanol used as a solvent and pyridine (1.27 mmol) as a base. They were set experimentally with respect to prior experience. The progress of reaction was monitored with TLC in system hexane/ethyl acetate (1:1). Then the mixture was separated by flash column chromatograph using gradient elution. Mobile phases were hexane and ethyl acetate again.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carboxamide, and friends who are interested can also refer to it.

Synthetic Route of 762240-92-6, These common heterocyclic compound, 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 ml flask, 50 ml of dimethylformamide (DMF)(3R) -3 – [(1,1-dimethylethoxycarbonyl) amino] -4- (2,4,5-trifluorophenyl)10.0 g and3- (Trifluoromethyl) -5,6,7,8-tetrahydro- [1,2,4] triazolo [4,3-a] pyrazine hydrochlorideAnd the mixture is stirred for 10 minutes to dissolve.The resulting reaction solution2-chloro-1, 3-dimethylimidazolinium chloride(2-chloro-1,3-dimethylimidazolinium chloride (DMC))5.3gAt 20 to 25 and stirred for 5 hours.To the reaction solution were added 100 ml of water and ethyl acetate (ethyl acetate (EA)) was added and the mixture was stirred for 30 minutes to separate the layers.In the resulting reaction solution, ethyl acetate(ethyl acetate (EA)) layer,This was concentrated under reduced pressure at 40 ,Is dissolved in 100 ml of isopropyl alcohol.0.8 ml of hydrochloric acid was added and the mixture was refluxed for 3 hours.The reaction was cooled to 5-10 [deg.] C,Stir for 3 hours.The precipitated solid is filtered off and washed with 10 ml of isopropyl alcohol.The obtained wetDried at 60 & lt; 0 & gt;Formula 1Indicated by(2R) -4-oxo-4- [3- (trifluoromethyl) -5,6-dihydro [1,2,4] triazolo [4,3- a] pyrazin-7 (8H) ] -1- (2,4,5-trifluorophenyl) butan-2-amine hydrochloride was obtained (yield: 97%).

Statistics shows that 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is playing an increasingly important role. we look forward to future research findings about 762240-92-6.

Electric Literature of 19847-12-2, A common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: TFA (0.75mmol) was added to a DCM/distilled H2O solution(2.5 mL, v/v = 1:1) of 1a (0.5mmol), and then stirred for 15 min. 2a (0.75mmol), K2S2O8 (1.5mmol) were added under air, sequentially an aqueous solution of FeSO4*7H2O in distilled H2O (1.25 mL) was slowly added by syringe pump(10 muL min-1). After complete addition, the reaction mixture was stirred for 5 h at ambient temperature. The mixture was neutralized by NaOH solution (1.0 M), the obtained aqueous phase was extracted with ether. The combined ethereal solution was dried over Na2SO4 and filtered. After evaporating the solvent, the arylated products 2-3aa and 3-3aa were isolated by flash chromatography (hexane:EtOAc = 5:1) in 67% and 27%yields, respectively.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1379338-74-5, Quality Control of 5,7-Dichloropyrido[3,4-b]pyrazine

1,1-dimethylethyl (3R)-3-(aminomethyl)-4-methyl-1-piperazinecarboxylate (143 mg, 0.624 mmol) and diisopropylethylamine (0.131 ml, 0.750 mmol) were added to a solution of 5,7-dichloropyrido[3,4-b]pyrazine (100 mg, 0.500 mmol) in dry N-methyl-2-pyrrolidone (NMP) (2 ml). The reaction was heated at 130 C. in the microwave for 30 min. After cooling, the reaction was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate (*2). The combined organics were washed with brine, dried using a hydrophobic frit and evaporated to give an orange oil. The residue was loaded in dichloromethane and purified on silica (25 g) using a 0-100% ethyl acetate/cyclohexane gradient. Appropriate fractions were combined and evaporated to give the title compound as yellow oil (162 mg). LCMS (Method A): Rt=1.2 min, MH+=393/395

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dichloropyrido[3,4-b]pyrazine, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1458-18-0

To a stirred mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (1.5 g, 6.756 nMol, 1 equiv) and (3-fluorophenyl) boronic acid (0.95 g, 6.790 nMol, 1.00 equiv) in 1, 4-dioxane (100 mL) and H 2O (5mL) were added Cs 2CO 3 (6.60 g, 0.020 nMol, 3 equiv) and Pd (dppf) Cl 2 (0.74 g, 0.001 nMol, 0.15 equiv) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 70 C under nitrogen atmosphere. The resulting mixture was filtered, the filter cake was washed with CH 2Cl 2 (1×30 mL) . The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH 2Cl 2 /EtOAc (4: 1) to afford methyl 3-amino-6-chloro-5- (3-fluorophenyl) pyrazine-2-carboxylate (900 mg, 47.30%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 282.0. 1H-NMR (300 MHz, Chloroform-d) delta 4.03 (3H, s) , 7.22 (1H , m) , 7.41-7.59 (2H , m) , 7.65 (1H , ddd) .

The synthetic route of Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.