Application of 122-05-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 122-05-4 as follows.
A mixture of pyrazine-2, 5-dicarboxylic acid (4.0Og, 23.79mmol) and hydrochloric acid (1 M in ethanol) was sealed in a pressure vessel and heated to 800C for 48 hours. The cloudy mixture was filtered through a short pad of celite and the filtrate was concentrated under vacuum. The residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated under vacuum to obtain the title compound (1.84g). MS (ESI) m/z 225.0 [M+H]+
According to the analysis of related databases, 122-05-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; N.V. ORGANON; WO2009/24550; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem