Synthetic Route of 59489-71-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59489-71-3, name is 2-Amino-5-bromopyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
5-bromo-piperazin-2-amine 4g, 22.99mmol, 1.00N was dissolved in 1,4-dioxane 68 mL and a mixed solution of 46mL ofanhydrous methanol, and then were added 3- (trifluoromethyl) phenylboronic acid 4.46g, 23.48mmol, 1.02N, sodium carbonate4.88g, 46.04mmol, 2.00N and Pd (PPh 3) 4 532mg, 0.46mmol, 0.02N, the whole system is heated to 135 C, stirred overnight,concentrated under reduced pressure Shrink, and finally by silica gel column chromatography, eluting with petroleum ether /ethyl acetate = 5: 1 to give yellow Colored solid of 5- (3- (trifluoromethyl) phenyl) piperazin-2-amine 4.4g, yield 80%
The synthetic route of 2-Amino-5-bromopyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shaanxi University of Technology; JIANG, MIN; LU, JIUFU; (17 pag.)CN103755695; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem