In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 939412-86-9
Intermediate 11-14. Step 7 : N-((3-chloropyrazin-2-yl)methyl)-9.9-difluoro-6-oxooctahvdro-lH-quinolizine-3- carboxamide To a solution of 9,9-difluoro-6-oxooctahydro-lH-quinolizine-3-carboxylic acid (1.9 g, 8.15 mmol) in THF (40 ml) was added (3-chloropyrazin-2-yl)methanamine hydrochloride (2.2 g, 12.22 mmol), HATU (4.65 g, 12.22 mmol) and TEA (6.81 ml, 48.9 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was treated with EA (200 ml) and water (200 ml), the organic layer was dried over Na2SC>4, filtered and concentrated. The residue was purified by column chromatography on silica gel eluted with PE/DCM/THF = 1/1/1 to give N-((3-chloropyrazin-2-yl)methyl)-9,9-difluoro-6-oxooctahydro-lH-quinolizine-3-carboxamide. lH NMR (400 MHz, CDC13) delta ppm 1.63 – 1.85 (m, 2 H), 1.99 – 2.29 (m, 3 H), 2.32 – 2.81 (m, 5 H), 3.46 – 3.62 (m, 1 H), 4.33 – 4.98 (m, 3 H), 8.15 – 8.24 (m, 1 H), 8.30 – 8.40 (m, 1 H).
The synthetic route of 939412-86-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph, A.; ALHASSAN, Abdul-Basit; BOGA, Sobhana Babu; GAO, Xiaolei; GUIADEEN, Deodialsingh; WANG, Jyhshing; XU, Jiayi; YU, Wensheng; YU, Younong; CAI, Jiaqiang; LIU, Shilan; WANG, Dahai; WU, Hao; YANG, Chundao; (211 pag.)WO2016/109221; (2016); A1;,
Pyrazine – Wikipedia,
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