Adding a certain compound to certain chemical reactions, such as: 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27825-21-4, Application In Synthesis of Methyl 3-chloropyrazine-2-carboxylate
A mixture of 1 (504?mg, 2.9?mmol) and O-benzylhydroxylamine (1073?mg, 8.72?mmol) in diisopropylethylamine (1.44?mL, 8.72?mmol) was irradiated in microwave at 100?C for 1?h. The reaction mixture was concentrated in vacuo and the residue was purified by silica gel chromatography using ethyl acetate and petroleum ether (1:4) as an eluent to provide 2 as a yellow solid in 16% yield, mp: 60-62?C. 1H NMR (400?MHz, DMSO-d6) delta 10.33 (s, 1H, N-H), 8.50 (d, J?=?2.3?Hz, 1H, pyrazine-H), 8.13 (d, J?=?2.3?Hz, 1H, pyrazine-H), 7.47 (dd, J?=?8.2, 1.6?Hz, 2H, Ph-H), 7.42-7.33 (m, 3H, Ph-H), 4.96 (s, 2H, CH2), 3.82 (s, 3H, CH3). 13C NMR (100?MHz, DMSO-d6) delta 165.51, 155.09, 146.75, 136.19, 134.63, 128.69 (2?xC), 128.30 (2?xC), 128.18, 125.53, 76.85, 52.44. ESI-MS: m/z 260.3 (M+1), 282.4 (M+23). C13H13N3O3 [259.3].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-chloropyrazine-2-carboxylate, and friends who are interested can also refer to it.
Reference:
Article; Sun, Lin; Gao, Ping; Dong, Guanyu; Zhang, Xujie; Cheng, Xiqiang; Ding, Xiao; Wang, Xueshun; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Menendez-Arias, Luis; Zhan, Peng; Liu, Xinyong; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 714 – 724;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem