These common heterocyclic compound, 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 23688-89-3
6-Chloropyrazine-2-carboxylic acid [CAS-RN: 23688-89-3] (300 mg, 1 .89 mmol,1.0 eq) was dissolved in 12 mL THF, and CDI (338 mg, 2.08 mmol, 1 eq) wasadded. Then, the reaction mixture was heated to 70C for 60 mm. On cooling, asolution of 1 -(2,2-difluoroethyl)piperazine [CAS-RN: 767609-14-3] (313 mg,2.08 mmol, 1 .03 eq) in 1 .5 mL THF was added. The reaction mixture was stirredat 70C for 2 h. The reaction mixture was partitioned between ethyl acetateand water. The water phase was extracted with ethyl acetate and the combinedorganic phases were washed with brine. The phases were separated by the useof a Whatman filter and the volatile components of the organic phase wereremoved in vacuo. Purification was conducted via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane -> hexane/ethyl acetate 2/1) to give 300 mg (55% yield of theory) of the title compound.UPLC-MS (Method 1): R = 0.75 mm; MS (EI0): m/z = 292 [M+1].
The synthetic route of 6-Chloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
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