Reference of 109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-methylpyrazine 0.478 (5 mmol) with 0.17 g of tetrabutylammonium bisulfate (0.5 mmol)5 ml of an aqueous solution of sodium hydroxide per liter was added,Heating to reflux, adding 5 mmol of p-dimethylaminobenzaldehyde,Reflux reaction. After completion of the reaction, the mixture was cooled to room temperature,The crude product was obtained by filtration and recrystallized from ethanol to give the product,Yield 56%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.
Reference:
Patent; University of Science and Technology of China; Zhang Guoqing; Chen Biao; Xu Cheng; Wang Hao; Du Jiajun; Bi Guoqiang; Luo Yi; (111 pag.)CN107118586; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem