Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., Product Details of 939412-86-9
To a solution of 3-(l -methoxy-2-methyl-l -oxopropan-2-yl)cyclohexanecarboxylic acid (1500 mg, 6.57 mmol) in THF (20 ml) was added HATU (3748 mg, 9.86 mmol), DIEA (3.44 ml, 19.71 mmol) and(3-chloropyrazin-2-yl)methanamine hydrochloride (1538 mg, 8.54 mmol) in one portion. After the addition was completed, the mixture was stirred at 25 C for 12h. The The reaction was quenched by addtion of water. The mixture was extracted with ethyl acetate several times. The combined organics was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The residure was purified by column chromagrophy on silica gel (PE/THF=4) to afford methyl 2-(3-(((3-chloropyrazin-2- yl)methyl)carbamoyl)cyclohexyl)-2-methylpropanoate as a light solid. XH NMR (400 MHz, METHANOL-^) delta ppm 1.01 – 1.07 (m, 1 H) 1.12 (s, 6 H) 1.26 (d, J=12.13 Hz, 1 H) 1.32 – 1.38 (m, 2 H) 1.57 – 1.62 (m, 1 H) 1.69 – 1.77 (m, 2 H) 1.86 (br. s., 2 H) 2.30 – 2.36 (m, 1 H) 3.65 (s, 3 H) 4.60 (s, 2 H) 8.31 – 8.34 (m, 1 H) 8.50 – 8.52 (m, 1 H) ppm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph, A.; BOGA, Sobhana Babu; GAO, Xiaolei; GUIADEEN, Deodialsingh; WANG, Jyhshing; LIU, Shilan; (85 pag.)WO2016/109219; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem