Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 6-chloropyrazine-2-carboxylate
A mixture of l-(4-((4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)methyl)benzyl)pyridin-2(lH)-one (339 mg, 1.05 mmol, 3.0 eq), methyl 6-chloropyrazine-2-carboxylate (150 mg, 0.87 mmol, 1.0 eq), Pd(dppf)Ci2 (71 mg, 0.061 mmol, 0.1 eq), K2C03 (240 mg, 1.74 mmol, 2.0 eq) in toluene/dioxane/H20 (10 niL/1 niL/1 mL) under N2 was stirred at 100 C for 5 h and then concentrated. The residue was extracted with EA (50 mL X 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was purified via pre-TLC to afford methyl 6-(4-((2-oxopyridin-l(2H)-yl)methyl)benzyl)pyrazine-2-carboxylate as a white solid (100 mg, 34%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 23611-75-8.
Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem