Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells was written by Xu, Bing;Xu, Xin;Zhang, Chenze;Zhang, Yuzhong;Wu, GaoRong;Yan, Mengmeng;Jia, Menglu;Xie, Tianxin;Jia, Xiaohui;Wang, Penglong;Lei, Haimin. And the article was included in Chemistry Central Journal in 2017.Category: pyrazines This article mentions the following:
To develop new ligustrazine derivatives with neuroprotective effects, the synthesis of several ligustrazine-vanillic acid amide derivatives I [R = hydroxy, methylamino, 2-aminonaphthyl, etc.] and screened their protective effect on the injured PC12 cells damaged by CoCl2. The results showed that most of the newly synthesized compounds I exhibited higher activity than ligustrazine, of which, compound I [R = 3-(dimethylamino)anilino] displayed the highest potency with EC50 values of 17.39 ± 1.34 μM. Structure-activity relationships were studied. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Category: pyrazines).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Category: pyrazines