A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates was written by Shirani, Hamid;Linares, Mathieu;Sigurdson, Christina J.;Lindgren, Mikael;Norman, Patrick;Nilsson, K. Peter R.. And the article was included in Chemistry – A European Journal in 2015.Quality Control of 5,8-Dibromoquinoxaline This article mentions the following:
By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moieties, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Quality Control of 5,8-Dibromoquinoxaline).
5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Quality Control of 5,8-Dibromoquinoxaline