An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system was written by Lang, Ming;Yao, Hui;Fu, Pengfei;Cai, Wei;Wang, Yuqiang;Yu, Pei. And the article was included in Research on Chemical Intermediates in 2015.Computed Properties of C8H12N2O This article mentions the following:
A novel and unexpected product, 5-amino-3,6-dimethyl-2-pyrazinecarbonitrile (3), was obtained during the attempted to synthesis of 3,5,6-trimethyl-2-pyrazinecarbonitrile (2) from its corresponding alc. (1) by the catalytic amount of KI or I2 in combination with TBHP as an external oxidant. The product was confirmed by ESI-MS, HRMS, 1H-NMR, 13C-NMR, and 2D-NMR. The mechanism for the formation of the amino group in the tetramethylpyrazine system is also proposed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Computed Properties of C8H12N2O