Adding a certain compound to certain chemical reactions, such as: 6705-33-5, name is Pyrazin-2-ylmethanol, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6705-33-5, name: Pyrazin-2-ylmethanol
To a solution of 2-pyrazinylmethanol (500 mg, 4.54 mmol) in DCM (15 mL) at 0 C was added thionyl chloride (0.66 mL, 9.1 mmol). The reaction mixture was stirred at 0 C for 3 h. The reaction mixture was concentrated in vacuo. The crude reaction mixture was triturated with Et2O to yield the title compound as a black solid (749 mg, 4.54 mmol, 99.9%), which was used without further purification.1H NMR (400 MHz, DMSO-d6) delta 4.87 (s, 2 H), 8.63-8.69 (m, 2 H), 8.82 (d, J = 1.39 Hz, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-ylmethanol, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHROVIAN, Christa C.; LETAVIC, Michael A.; RECH, Jason C.; RUDOLPH, Dale A.; JOHNSON, Akinola Soyode; STENNE, Brice M.; WALL, Jessica L.; (533 pag.)WO2018/67786; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem