Pyridazine analogs of biologically active compounds. Part III. Synthetic investigations directed to azanicotines and congeners was written by Heinisch, Gottfried;Jentzsch, Alexander;Kirchner, Ingrid;Loetsch, Gerhard. And the article was included in Vestnik Slovenskega Kemijskega Drustva in 1986.Electric Literature of C7H8N2O2 This article mentions the following:
Synthetic approaches providing access to novel analogs of nicotine, e.g., I (R = Me) and nornicotine, e.g., I (R = H) are investigated. Homolytic α-N-amidoalkylation permits C-C bond formation between pyridazine (C-4), pyrimidine (C-4), pyrazine (C-2) or quinoline (C-4) and N-formyl- or N-acetyl-pyrrolidine. The N-formylnornicotinoids are converted into 1-methyl-2-heteroarylpyrrolidines by reduction Hydrolysis of the corresponding N-acetyl derivatives affords aza-nor-nicotines and related compounds In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Electric Literature of C7H8N2O2).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Electric Literature of C7H8N2O2