Instances of nonelectrolyte solvation leading to less pronounced rate enhancements of ester hydrolyses in dipolar aprotic solvents: the possibility of hydrolysis via conjugate base formation in the case of ethyl indole-2-carboxylate and methyl 4-pyridylacetate was written by Rao, G. Venkoba;Balakrishnan, M.;Venkatasubramanian, N.;Subramanian, P. V.;Subramanian, V.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1978.Computed Properties of C7H8N2O2 This article mentions the following:
The kinetics of alk. hydrolysis of the heterocyclic esters I (RR1 = benzo, X = NH; R = R1 = H, X = O, S), II (R = CH2CO2Et, CO2Et, R1 = R2 = H; R = R1 = H, R2 = CH2CO2Me, CO2Et; R = R2 = H, R1 = CO2Et, CH2CO2Et), III, BzOEt, and PhCH2CO2Et were studied in binary solvent mixtures of Me2SO-H2O and EtOH-H2O. The rate data for I (RR1 = benzo, X = NH) and II (R = R1 = H, R2 = CH2CO2Me) indicated the possibility of an E1cb route for their hydrolysis. The hydrolysis of heterocyclic esters constitute a unique case in which the rate enhancements of ester saponification on transfer from protic to dipolar aprotic solvents are governed by the solvation of the nonelectrolyte (ester) mol. by Me2SO, a factor hitherto relegated to the background. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Computed Properties of C7H8N2O2).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Computed Properties of C7H8N2O2