Degradation products from amiloride hydrochloride was written by Goerlitzer, Klaus;Huth, Silke;Goessnitzer, Edith;Wendelin, Winfried. And the article was included in Scientia Pharmaceutica in 2004.Reference of 1458-01-1 This article mentions the following:
The degradation of amiloride hydrochloride (I) in acetate buffer pH 4.6 (reflux) was studied. The following products were obtained; amiloride acetate, 3-chloropyrazin-2,6-diamine, and 5-allophanoyl-3-chloropyrazin-2,6-diamine. The heating of I in DMF led to the formation of 2,7-diamino-6-chloro-4(3H)pteridinone. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Reference of 1458-01-1).
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 1458-01-1