Method of predicting the site of alkylation of heterocyclic polyazines from kinetic data on model compounds was written by Zoltewicz, J. A.;Deady, L. W.. And the article was included in Tetrahedron in 1972.Synthetic Route of C7H5N3 This article mentions the following:
A method is presented which enables calculation of isomer ratios resulting from the N-methylation of polyazines in Me2SO. The method assumes that substituent and annular N atom effects on reactivity are additive in the absence of steric factors. Kinetic studies on model azines provide rate factors which are employed in the calculations Observed and calculated isomer ratios are compared for a number of polyazines. An extension to N-oxidation is suggested. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Synthetic Route of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Synthetic Route of C7H5N3