Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives was written by Wang, Fang;Sun, Jun-Rong;Huang, Mei-Yan;Wang, Hui-Ying;Sun, Ping-Hua;Lin, Jing;Chen, Wei-Min. And the article was included in European Journal of Medicinal Chemistry in 2014.Name: (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:
Rosiglitazone has shown promising anti-inflammation effect. To develop preferable anti-inflammatory agents, twenty-two rosiglitazone analogs were synthesized and their anti-inflammatory activity was evaluated. Among these compounds, I and II displayed excellent inhibitory activities on the production of inflammatory mediators, including nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Furthermore, I and II showed suppression effects on the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, and this suppression effects could be partially reversed by GW9662, which is a peroxisome proliferator-activated receptor γ (PPARγ) antagonist. Addnl., our docking results exhibited the well combination of I and II to PPARγ. So the anti-inflammation activity of I and II was due at least in part, to their interaction with PPARγ. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Name: (3,5,6-Trimethylpyrazin-2-yl)methanol).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Name: (3,5,6-Trimethylpyrazin-2-yl)methanol