Design, synthesis and evaluation of novel chloro-oxime derivatives for neurodegenerative diseases was written by Zhang, Aijun;Fu, Pengfei;Zhang, Zaijun;Chen, Haiyun;Yu, Pei. And the article was included in Journal of Pharmaceutical and Biomedical Sciences in 2016.Synthetic Route of C8H12N2O This article mentions the following:
Neurodegenerative disease is a fatal disease of the human nervous system, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and related polyglutamine expansion diseases. The US FDA had approved several drugs to treat neurodegenerative diseases, however, almost none of them could delay progress of these diseases and offer cure. A key mol. pathway implicated in neurodegenerative diseases is the misfolding aggregation and accumulation of proteins in neurons. Chloro-oxime derivatives, such as bimoclomol and arimoclomol, promote the expression of heat shock proteins and improve the abilities of normal protein folding and degrade misfolded proteins. Based on the structure of bimoclomol and arimoclomol, we substituted the pyridine and piperazine by TMP and other amino groups, and synthesized a series of novel chloro-oxime derivatives Among these chloro-oxime derivatives, compounds 9b and 13b were demonstrated to be neuroprotective against MG-132-induced neurotoxicity in SH-SY5Y cells. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Synthetic Route of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Synthetic Route of C8H12N2O