Substituent-directing effects in the homolytic acylation of pyrazine derivatives was written by Houminer, Y.;Southwick, E. W.;Williams, D. L.. And the article was included in Journal of Organic Chemistry in 1989.COA of Formula: C7H8N2O2 This article mentions the following:
The homolytic acylation of various monosubstituted pyrazines was studied for a wide spectrum of substituents. MeO and Cl substituents directed ortho to yield the corresponding 2,3-disbustituted pyrazines. Ac, CO2Et, and CONH2 groups directed para, leading to the corresponding 2,5-disubstituted pyrazines. These selectivities result from the combination of the inductive and resonance effects of the substituents. The synthetic potential of the acylation reaction is demonstrated in the preparation of some novel pyrazine flavorants, e.g., I. Thus, 2-chloropyrazine was treated with Me2CHCHO, Me3COOH, FeSO4, and H2SO4 in H2O to give (chloropyrazinyl)methylpropanone II. Treating furfuryl mercaptan with NaOEt and then II in EtOH gave 32% I. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1COA of Formula: C7H8N2O2).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.COA of Formula: C7H8N2O2