Pi-electron delocalization in aza derivatives of naphthalene and indole was written by Mohajeri, Afshan;Shahamirian, Mozhgan. And the article was included in Computational & Theoretical Chemistry in 2011.Reference of 322-46-3 This article mentions the following:
The influence of increasing number of nitrogens and their sequences on π-electron delocalization of aza derivatives of naphthalene and indole was studied using different quant. descriptors including the geometry-based harmonic oscillator model of aromaticity (HOMA), magnetic index nucleus independent chem. shift (NICS) and electronic indexes. Also the authors used HOMO-LUMO gap and anisotropy of magnetic susceptibility as global descriptors. N-N bond destabilizes both endosubstituted naphthalenes and indoles and the most stable isomers are those having smallest number of such units. All studied indexes except HOMA indicate aromaticity lowering with an increase of the number of N atoms in a ring, however, the anomaly high aromatic characters are observed for the cases when N-N bond is formed. Anal. of at. charge d. shows that the maximum local aromaticity belongs to position isomer in which the average over at. charges on heteroatoms is less in the individual rings. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Reference of 322-46-3