Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke was written by Sun, Yewei;Jiang, Jie;Zhang, Zaijun;Yu, Pei;Wang, Linda;Xu, Changlin;Liu, Wei;Wang, Yuqiang. And the article was included in Bioorganic & Medicinal Chemistry in 2008.COA of Formula: C8H12N2O This article mentions the following:
Ischemic stroke results from brain blood vessel blockage by thrombus, and produces neuronal cell damage and death. While thrombolytic therapy with tPA has achieved some success in clinic, the strategy of using neuroprotective agents to treat ischemic stroke has been disappointing thus far. In the present work, the authors synthesized TBN, a derivative of the clin. useful stroke drug TMP armed with a powerful free radical-scavenging nitrone moiety. TBN retains the thrombolytic activity of the parent TMP and possesses strong antioxidative properties. TBN demonstrates significant activity in the rat MCAo stroke model. The results suggest that design of mols. possessing both thrombolytic and neuroprotective properties may be a novel strategy for effective stroke therapeutics. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3COA of Formula: C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.COA of Formula: C8H12N2O