Hydrophobicity parameters determined by reversed-phase liquid chromatography. XIV. Application of a new hydrogen-accepting scale of monosubstituted pyrazines to analysis of the relationship between octanol-water partition coefficients and retention factors measured in different mobile phases was written by Yamagami, Chisako;Haraguchi, Miyako. And the article was included in Chemical & Pharmaceutical Bulletin in 2000.HPLC of Formula: 6924-68-1 This article mentions the following:
The authors recently proposed a new H-accepting scale, SHA, for monosubstituted pyrazines, and demonstrated that this parameter works effectively in expressing the relation between log P (P: 1-octanol/H2O partition coefficient) and log k’ (k’: retention factor derived from reversed phase liquid chromatog.) with aqueous MeOH solutions as the mobile phase, according to the equation: log k’ = a log P+ρσ1+sSHA+constant, where σ1 represents the electronic substituent constant The authors have extended the same treatment to anal. of log k’ measured in mobile phases containing different organic modifiers such as 1-propanol, MeCN, and dioxane, and found that the above equation is still useful. By comparing the correlations obtained, the parameter SHA could be universally used for representing the difference in H-bonding effects involved in different partitioning systems. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1HPLC of Formula: 6924-68-1).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.HPLC of Formula: 6924-68-1