Chemotherapeutic studies on schistosomiasis. XXXVI. Synthesis of 4-phenyl- and 4-allyl-5-(2-pyrazinyl)-1,2,4-triazole-3-thione derivatives was written by Xu, Maoli;Lei, Xinghan. And the article was included in Yaoxue Xuebao in 1985.Quality Control of Ethyl pyrazine-2-carboxylate This article mentions the following:
Twenty-eight title compounds (I; R = Ph, allyl; R1 = H, alkyl, acyl, dialkylaminomethyl, cyclic aminomethyl, etc.), effective schistosomicides at 1050 mg/kg in mice, were prepared Thus, heating 0.2 mol II (R2 = EtO) with N2H4·H2O in EtOH at 40-50° gave hydrazide II (R2 = H2NNH), which (0.075 mol) was heated with 0.09 mol PhNCS in EtOH at 110-50° to give 60-70% II (R2 = PhNHCSNHNH) (III). Heating 0.08 mol III with 2 N NaOH at 70° gave 80-90% IV·Na (R = Ph), which (0.0045 mol) was heated with 0.0055 mol Me2SO4 in EtOH at 75° to give I (R = Ph, R1 = H). In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Quality Control of Ethyl pyrazine-2-carboxylate).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Quality Control of Ethyl pyrazine-2-carboxylate