Practical Approach for the Preparation of α-Keto Amides by Direct Aminocarbonylation of Carboxylic Esters with a Carbamoylsilane was written by Han, Yuling;Han, Shenghua;Ma, Jiangwen;Li, Weidong;Chen, Jianxin. And the article was included in Synlett in 2020.Related Products of 6924-68-1 This article mentions the following:
A novel and practical method has been developed for the preparation of α-keto amides e.g., Me 3-[(dimethylcarbamoyl)carbonyl]benzoate by a catalyst-free aminocarbonylation of carboxylic esters RC(O)OR1 (R = CF3, 4-nitrophenyl, 6-fluoropyridin-3-yl, pyrazin-2-yl, etc.; R1 = Me, Et, Ph) with N,N-dimethylcarbamoyl(trimethyl)silane under neutral conditions. A new protocol for the synthesis of N,N-dimethyl-β-ethoxy-α,β-dioxo-propionamide was also developed by using this method. In the case of di-Et oxalate, only one ester group reacted selectively with 1.2 equiv of the N,N-dimethylcarbamoyl(trimethyl)silane, leading to the formation of N,N-dimethyl-β-ethoxy-α,β-dioxo-propionamide. The reaction was suitable for aryl, hetaryl, or open-chain esters containing strongly electron-withdrawing groups. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Related Products of 6924-68-1).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines are chemical compounds (technically called âmethoxypyrazinesâ? found in grape skin and stems that are responsible for many âgreenâ?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Related Products of 6924-68-1