Alkylamino derivatives of pyrazinamide: Synthesis and antimycobacterial evaluation was written by Servusova, Barbora;Paterova, Pavla;Mandikova, Jana;Kubicek, Vladimir;Kucera, Radim;Kunes, Jiri;Dolezal, Martin;Zitko, Jan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Synthetic Route of C5H6N4O This article mentions the following:
A series of pyrazinamide derivatives with alkylamino substitution was designed, synthesized and tested for their ability to inhibit the growth of selected mycobacterial, bacterial and fungal strains. The target structures were prepared from the corresponding 5-chloro or 6-chloropyrazine-2-carboxamide by nucleophilic substitution of chlorine by various non-aromatic amines (alkylamines). To determine the influence of alkyl substitution, corresponding amino derivatives and compounds with phenylalkylamino substitution were prepared Some of the compounds exerted antimycobacterial activity against Mycobacterium tuberculosis H37Rv significantly better than standard pyrazinamide and corresponding starting compounds Basic structure-activity relations are presented. Only weak antibacterial and no antifungal activity was detected. In the experiment, the researchers used many compounds, for example, 5-Aminopyrazine-2-carboxamide (cas: 89323-09-1Synthetic Route of C5H6N4O).
5-Aminopyrazine-2-carboxamide (cas: 89323-09-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Synthetic Route of C5H6N4O