Using Intelligent/Random Library Screening To Design Focused Libraries for the Optimization of Homogeneous Catalysts: Ullmann Ether Formation was written by Fagan, Paul J.;Hauptman, Elisabeth;Shapiro, Rafael;Casalnuovo, Albert. And the article was included in Journal of the American Chemical Society in 2000.Product Details of 322-46-3 This article mentions the following:
A 96-member pyridine library consisting of both rationally chosen and random members was used to screen Ullmann ether forming reactions. The reaction of 2-bromo-4,6-dimethylaniline and other substrates with a variety of alkoxides was studied under different conditions with the aid of an automated liquid handler. From the results of the 96-member library screening, a structure activity profile was determined which led to the design of smaller focused ligand libraries. The focused libraries produced a higher frequency of hits compared to the original 96-member library. Some of the more effective ligands discovered in this work are generally useful for alkoxylation of a variety of substrates, and also functioned in intramol. ether forming reactions. This work demonstrates for homogeneous catalysis the analogy to the pharmacol. model of drug discovery. By using a large library to screen for a lead compound followed by screening the diversity space closest to the lead, a larger fraction of increased performance ligands was discovered. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines are chemical compounds (technically called âmethoxypyrazinesâ? found in grape skin and stems that are responsible for many âgreenâ?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Product Details of 322-46-3