In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 63286-28-2
(2) To a 100 mL eggplant flask were added 2-chloro-3-hydrazinylpyrazine (370 mg), diisopropylethylamine (1.3 mL), acetonitrile (15 mL), and the above 5-azaspiro[2.5]octane-5-carbonyl chloride (435 mg) under argon gas flow, and the resulting mixture was stirred at 80 C. for 100 minutes. After the reaction was completed, the mixture was concentrated under reduced pressure, the resulting residues were subjected to silica gel chromatography using YAMAZEN medium pressure preparative (Silica L (40 g)), the fractions comprising the target compound (Rf value=0.4 (hexane:ethyl acetate=1:1)) were collected, and concentrated under reduced pressure to give the title compound (330 mg) (yield 47%) as a slightly yellow foam. MS(CI) m/z: 282/284 [M+H]+
The synthetic route of 63286-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem