Reddy, B. Venkata published the artcileStudies on synthesis and antifungal activity of pyrazine connected 1,2,4-triazol derivatives, Synthetic Route of 4604-72-2, the publication is European Journal of Biomedical and Pharmaceutical Sciences (2017), 4(8), 1022-1026, database is CAplus.
Encouraged by the broad spectrum of biol. activities of pyrazine and 1,2,4-triazoles, a series of 4-(benzylidene-amino)-5-(4-methyl-2-pyrazin-2-yl-thiazol-5-yl)-4H-[1,2,4]triazole-3-thiol and its derivatives I [R = H, Me, Br, etc.] were synthesized by involving various intermediates like 4-methyl-2-pyrazin-2-yl-thiazole-5-carboxylic acid Et ester, 4-methyl-2-pyrazin-2-yl-thiazole-5-carboxylic acid hydrazide, potassium N-(4-methyl-2-pyrazine-2-yl-thiazole-5-carbonyl)-hydrazine carbodithioate and 3-methyl-5-(4-methyl-2-pyrazin-2-yl-thiazol-5-yl)-[1,2,4]-triazol-4-ylamine and from pyrazine-2-carbothioic amide as raw material. Structures of the synthesized compounds I were elucidated by IR, 1H-NMR and mass spectral data. All of the compounds I were tested for antifungal activity and found that all the compounds I exhibited marginal to good antifungal activity.
European Journal of Biomedical and Pharmaceutical Sciences published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Synthetic Route of 4604-72-2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem