Kaliszan, Roman published the artcileStudies on the quantitative structure-activity relationships in pyrazine carbothioamide derivatives, Synthetic Route of 4604-72-2, the publication is Polish Journal of Pharmacology and Pharmacy (1978), 30(4), 579-83, database is CAplus and MEDLINE.
Quant. structure-activity relations of 1 pyrazinecarbothioamides I (R = NMe2, SPh, morpholino, etc.) are presented for tuberculostatic potency in vitro. The tuberculostatic activities of I were related both to the size of the substituent and to electronic properties of the mol. An equation [log(1/C) = -0.0221MR + 0.0073λ – 1.6792; MR = molar refractivity calculated for substituents, λ = wave length maximum absorption (nm) C = min. concentration causing inhibition of bacterial growth] was obtained, statistically significant on the 99% level, which described ∼71% of variance of activity data for I as a function of molar refractivity of the substituent and the wave length at which absorption max occurred.
Polish Journal of Pharmacology and Pharmacy published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Synthetic Route of 4604-72-2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem