Jones, James Holden published the artcilePyrazine diuretics. V. N-Amidino-3-aminopyrazinecarboxamidines and analogous 2,4-diaminopteridines, Recommanded Product: 3-Amino-6-chloropyrazine-2-carboxamide, the main research area is PYRAZINES DIURETICS; AMIDINOPYRAZINECARBOXAMIDINES; DIAMINOPTERIDINES DIURETICS; DIURETICS PYRAZINES; PTERIDINES DIAMINO.
The synthesis of a series of N-amidino-3-aminopyrazinecarboxamidines (I), principally by the reaction of a 3-aminopyrazinecarbonitrile with an appropriate guanidine, is described. Cyclization of selected members of this series afforded the analogous 2,4-diaminopteridines (II). The required 3-aminopyrazinecarbonitriles were prepared from the corresponding carboxamides; 3-amino-5,6-dichloropyrazinecarbonitrile yielded a variety of 5-substituted derivatives by nucleophilic displacement of the 5-chloro group. I exhibited diuretic activity as measured by several assay methods in rats and dogs. These compounds were generally less active than the corresponding 2,4-diaminopteridines which, in turn, were less potent than the corresponding N-amidino-3-aminopyrazine-carboxamides. 16 references.
Journal of Medicinal Chemistry published new progress about Diuretics. 1125-56-0 belongs to class pyrazines, name is 3-Amino-6-chloropyrazine-2-carboxamide, and the molecular formula is C5H5ClN4O, Recommanded Product: 3-Amino-6-chloropyrazine-2-carboxamide.