Adding a certain compound to certain chemical reactions, such as: 873-42-7, name is 2-Amino-3,5-dichloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 873-42-7, Product Details of 873-42-7
General procedure: To the mixture of o-aminohalopyrazine (0.8 mmol) 1 in solvent was added NaOH (2.8 mmol, 3.5 eq), and stirred at T’ for 20 min. Isothiocyanate (0.92 mmol, 1.15 eq) 2 was added to the solution dropwise and heated at T”. The progress of the reaction was monitored by TLC. When all the starting material had been consumed, the mixture was allowed to room temperature. The product was isolated by the method described in Table 1.
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Reference:
Article; Kwak, Se Hun; Lee, Gee-Hyung; Gong, Young-Dae; Bulletin of the Korean Chemical Society; vol. 33; 12; (2012); p. 4271 – 4274;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem