Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5521-58-4, name is 5-Methylpyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 5521-58-4
l-Chloro-N,N,2-trimethyl-l-propenylamine (0.1 mL, 0.75 mmol) was added to a solution of3-{[5-(azetidin-l-ylcarbonyl)-3-chloropyridin-2-yl]oxy}-5-[((15)-2-{[(l,l- dimethylethyl)(dimethyl)silyl]oxy}-l-meth.ylethyl)oxy]benzoic acid (0.3 g, 0.58 mmol) in DCM (10 mL) and stirred for 1 hour. 2-Amino-5-methylpyrazine (126 mg, 1.15 mmol) then pyridine (0.094 mL, 1.15 mmol) were added and the mixture stirred for a further 30 mins before being reduced in vacuo and partitioned between ethyl acetate (50 mL) and water (50 mL). The aqueous layer was further extracted into ethyl acetate (50 mL) and the combined organics washed with water (50 mL), brine (50 mL), dried (MgSO4), and reduced in vacuo. The crude oil was chromatographed on silica, eluting with 40-100% ethyl acetate in isohexane, to give the title compound as an oil (180 mg). 1H NuMR delta (CDCl3): 0.00 (s, 3H), 0.03 (s, 3H), 0.82 (s, 9H), 1.28 (d, 3H), 2.35 (quin, 2H), 2.51 (s, 3H), 3.63 – 3.78 (m, 2H), 4.19 (t, 2H), 4.32 (t, 2H), 4.47 – 4.51 (m, IH), 6.95 (t, IH), 7.23 – 7.24 (m, IH), 7.35 (t, IH), 8.08 (s, IH), 8.12 (d, IH), 8.21 (d, IH), 8.45 (s, IH), 9.51 (d, IH); m/z 612 (M+H)+
According to the analysis of related databases, 5521-58-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/7041; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem