Zhou, Jiadi published the artcileδ-Regioselective heteroarylation of free alcohols through 1,5-hydrogen-atom transfer, Recommanded Product: 2,3,5-Trimethylpyrazine, the main research area is heteroarene alkyl alc silver catalyst regioselective heteroarylation; alkyl heteroarene preparation.
An efficient silver-catalyzed δ-regioselective C(sp3)-H heteroarylation of free alcs. was developed. Various alcs. reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp2)-H alkylation products in 31-89% yields. Notably, all types (1°, 2°, and 3°) of δ-C(sp3)-H bonds in the alcs. was regioselectively activated. This protocol provided a platform to access divergent functionalizations of alcs. and heteroaryls by forming the challenging δ-selective C(sp3)-C(sp2) bond.
Organic Chemistry Frontiers published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Recommanded Product: 2,3,5-Trimethylpyrazine.