1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1458-01-1
A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (40.0 g, 197 mmol), 2- [(E)-2-ethoxyethenyl]-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane (84 ml, 400 mmol), SPhos (8.11 g, 19.7 mmol), palladium(ll) acetate (2.22 g, 9.87 mmol) and K3P04 (83.8 g, 395 mmol) in water:MeCN (2:3, 350 ml) was stirred at 80 ¡ãC for 2 h then allowed to cool to RT. The solid was collected by filtration then washed with EtOAc (100 ml) and water (100 ml) then dried in vacuo to afford the product as a brown solid (36.7 g, 76percent). 1 H NMR (500 MHz, DMSO-cfe) delta 7.15 (d, J = 12.2 Hz, 1 H), 6.79 (s, 4H), 5.97 (d, J = 12.2 Hz, 1 H), 3.91 (q, J = 7.0 Hz, 2H), 3.72 (s, 3H), 1.25 (t, J = 7.0 Hz, 3H). LC/MS (System A): m/z (ESI+) = 239 [MH+], Rt = 0.88 min, UV purity = 98percent.
Statistics shows that 1458-01-1 is playing an increasingly important role. we look forward to future research findings about Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate.
Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan, David; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; WENT, Naomi; (261 pag.)WO2018/96325; (2018); A1;,
Pyrazine – Wikipedia,
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