On April 2, 2022, Bashmakova, Eugenia E.; Panamarev, Nikita S.; Kudryavtsev, Alexander N.; Frank, Ludmila A. published an article.COA of Formula: C26H21N3O3 The title of the article was N-extended photoprotein obelin to competitively detect small protein tumor markers. And the article contained the following:
Two variants of Ca2+-regulated photoprotein obelin, extended from the N-terminus with small tumor markers – melanoma inhibitory activity protein (MIA) and survivin, one of the protein inhibitors of apoptosis, were designed, obtained and studied. Both domains in the obtained hybrid proteins exhibit the properties of the initial mols.: the main features of Ca2+-triggered bioluminescence are close to those of obelin, and the tumor markers domains are recognized and bound by the corresponding antibodies. The obtained hybrids compete with the corresponding tumor markers for binding with antibodies, immobilized on the surface and their use has been shown to be promising as bioluminescent labels in a one-stage solid-phase competitive immunoassay. The experimental process involved the reaction of 8-Benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one(cas: 55779-48-1).COA of Formula: C26H21N3O3
The Article related to photoprotein obelin protein tumor marker, competitive assay, genetic fusion, photoprotein obelin, tumor marker, Biochemical Methods: Biological and other aspects.COA of Formula: C26H21N3O3