On January 2, 2014, Do, Steven; Hu, Huiyong; Kolesnikov, Aleksandr; Tsui, Vickie H.; Wang, Xiaojing published a patent.SDS of cas: 87486-34-8 The title of the patent was 5-Azaindazole compounds as Pim kinase inhibitors and their preparation. And the patent contained the following:
5-Azaindazole compounds of formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Compounds of formula I wherein R1 is (un)substituted 5- to 6-membered heteroaryl; R2 is (un)substituted Ph and (un)substituted 6-membered heteroaryl; and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their Pim kinase inhibitory activity (data given). The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).SDS of cas: 87486-34-8
The Article related to azaindazole preparation pim kinase inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.SDS of cas: 87486-34-8