On December 17, 2020, Wang, Jin; Guo, Wen-Hao; Qi, Xiaoli; Wang, Luhua; Liu, Yang; Nomie, Krystle J. published a patent.Synthetic Route of 87486-34-8 The title of the patent was Preparation of small molecule proteolysis-targeting chimeras for use as Bruton tyrosine kinase inhibitors. And the patent contained the following:
Title compounds I [A = BTK binder; L = linker; B = E3 ligase binder], and their pharmaceutically acceptable salts, are prepared and disclosed as Bruton tyrosine kinase inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in BTK inhibition assays, e.g., II demonstrated an IC50 value of 1.8 nM. The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).Synthetic Route of 87486-34-8
The Article related to pyrimidinylpiperidine pyrazolo preparation bruton tyrosine kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 87486-34-8