On August 21, 2014, Boruah, Anima; Hosahalli, Subramanya; Panigrahi, Sunil Kumar published a patent.Safety of 3,5-Dibromo-1-methylpyrazin-2(1H)-one The title of the patent was Preparation of indole derivatives for use as kinase inhibitors. And the patent contained the following:
Title compounds I [R1 = alkyl, cycloalkyl, (un)substituted aryl, etc.; R2 = substituted pyrazine or imidazopyrazine; X = CH2 or CH2CH2], and their pharmaceutically acceptable salts, are prepared and disclosed as kinase inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in BTK TR-FRET kinase activity assays (data given). The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).Safety of 3,5-Dibromo-1-methylpyrazin-2(1H)-one
The Article related to indole preparation kinase inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of 3,5-Dibromo-1-methylpyrazin-2(1H)-one