On December 1, 2019, Pinto da Silva, Luis; Nunez-Montenegro, Ara; Magalhaes, Carla M.; Ferreira, Paulo J. O.; Duarte, Diana; Gonzalez-Berdullas, Patricia; Rodriguez-Borges, Jose E.; Vale, Nuno; Esteves da Silva, Joaquim C. G. published an article.HPLC of Formula: 55779-48-1 The title of the article was Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer. And the article contained the following:
While photodynamic therapy is known for significant advantages over conventional cancer therapies, its dependence on light has limited it to treating tumors on or just under the skin or on the outer lining of organs/cavities. Herein, we have developed a single-mol. photosensitizer capable of intracellular self-activation and with potential tumor-selectivity due to a chemiluminescent reaction involving only a cancer marker. Thus, the photosensitizer is directly chemiexcited to a triplet excited state capable of generating singlet oxygen, without requiring either a light source or any catalyst/co-factor. Cytotoxicity assays involving the photosensitizer show significant toxicity toward tumor cells, even better than reference drugs, while not inducing toxicity toward normal cells. This work provides a proof-of-concept for a novel type of photosensitizer that eliminates the current restrictions that photodynamic therapy presents regarding tumor size and localization. The experimental process involved the reaction of 8-Benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one(cas: 55779-48-1).HPLC of Formula: 55779-48-1
The Article related to chemiluminescent photosensitizer cancer pdt photodynamic therapy, breast cancer, cancer, chemiluminescence, coelenterazine, photodynamic therapy, photosensitizer, prostate cancer and other aspects.HPLC of Formula: 55779-48-1