Meng, Lili; Sun, Changli; Zhang, Chunyan; Song, Shihao; Sun, Xiuyun; Ju, Jianhua; Deng, Yinyue published the artcile< Efficacy of compounds isolated from Streptomyces olivaceus against the morphogenesis and virulence of Candida albicans>, Computed Properties of 2873-36-1, the main research area is Streptomyces Candida morphogenesis virulence; Candida albicans; Streptomyces olivaceus; hypha formation; virulence.
Candida albicans is a type of commensal fungi which causes serious infections in immunocompromised patients and contributes to high mortality. In the present study, we identified that the extract from Streptomyces olivaceus SCSIO T05 inhibited hypha and biofilm formation of C. albicans. Seven compounds were isolated and evaluated for their effects on the biol. functions and virulence of C. albicans. Two leading compounds, compound 1 (sorbicillin) and compound 2 (3-methyl-N-(2′-phenethyl)-butyrylamide) were identified as exhibiting strong activity against C. albicans morphol. transition, adhesion activity, cytotoxicity, and adhesion to human cells, in a dose-dependent manner. Notably, compound 2 inhibited C. albicans infection in mouse oral mucosal models. Transcriptomic anal. and real-time PCR results revealed that compound 2 most likely inhibited the biol. functions of C. albicans cells by regulating the expression levels of HWP1, TEC1, ALS1, IFD6, and CSH1, which are associated with filament formation and cell adhesion. Our results suggest that the candidate compounds present excellent efficacy against C. albicans pathogenicity and that they can be developed as potential options for the clin. treatment of candidiasis.
Marine Drugs published new progress about Agglutinin-like protein 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Computed Properties of 2873-36-1.