19745-07-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19745-07-4, name is 2,5-Dichloropyrazine, A new synthetic method of this compound is introduced below.
A mixture of tert-butyl (R)-3-(3-amino-4-((trans-4-((tert- butyldimethylsilyl)oxy)cyclohexyl)(isobutyl)amino)phenyl)butanoate (500 mg, 0.97 mmol), 2,5-dichloropyrazine (290 mg, 1 .94mmol), Pd2(dba)3 (178 mg, 0.194 mmol), Xantphos (225 mg, 0.388 mmol) and CS2CO3 (630 mg, 1 .94 mmol) in toluene (5 ml.) was stirred at 100C under N2 atmosphere overnight. The resulting mixture was partitioned between EtOAc and H20. After the layers were separated, the organic layer was washed with brine, dried over Na2S04, filtered and concentrated to give the crude product which was purified by flash chromatography (silica gel, 0-30% EtOAc in PE) to afford the title compound (410 mg, 67% yield). LCMS (ESI) m/z calcd for C34H55CIN4O3S1: 630.37. Found: 631 .39/633.40 (M/M+2)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; KAZMIERSKI, Wieslaw M.; (62 pag.)WO2019/116171; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem