Pyrazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2. It is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. 22047-25-2, formula is C6H6N2O, Name is Acetylpyrazine. It is a deliquescent crystal or wax-like solid with a pungent, sweet, corn-like, nutty odour. Application In Synthesis of 22047-25-2.
Ramesh, G.;Sharath Kumar, N. M.;Raghavendra Kumar, P.;Suchetan, P. A.;Devaraja, S.;Sabine, Foro;Nagaraju, G. research published 《 Synthesis, characterisation, crystal structures, anticoagulant and antiplatelet activity studies of new 2,6-dipyrazinylpyridines with pendant trimethoxyphenyl》, the research content is summarized as follows. Three new 2,2′-[4-(n,n’,n”-trimethoxyphenyl)pyridine-2,6-diyl]dipyrazines (1-3) were synthesized by facile one-pot procedure from 2-acetylpyrazine and n,n’,n”-trimethoxybanzaldehydes in methanol in presence of KOH and ammonia solution The compounds 1-3 were characterized by 1H and 13C NMR, FT-IR, UV-Visible and fluorescence spectroscopy. The mol. structures of compounds 1, 2 and 3 were also confirmed by single crystal x-ray diffraction. There exists CH···N and CH···O type intermol. secondary interactions in the crystalline solids of 1, 2 and 3 resulting in supramol. structures. These compounds were explored for anticoagulant and antiplatelet studies. All the compounds prolonged the clotting time of citrated human plasma in both PRP and PPP. In PRP, they enhanced clotting time from control by 60-100 Sec whereas in PPP by 80-140 Sec. In addition, 2 inhibited the ADP induced platelet aggregation whereas 1 and 3 did not show any role. The inhibition percentage of 2 was found to be 14. Moreover, these compounds were found nontoxic to RBCs.
22047-25-2, 2-Acetylpyrazine has been identified as one of the volatile flavor constituents in popcorn, wheat and rye bread crust.
2-Acetylpyrazine, also known as 1-pyrazinylethanone or fema 3126, belongs to the class of organic compounds known as aryl alkyl ketones. These are ketones have the generic structure RC(=O)R’, where R = aryl group and R’=alkyl group. 2-Acetylpyrazine exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 2-acetylpyrazine is primarily located in the cytoplasm. 2-Acetylpyrazine has a bitter, bread crust, and chip taste.
2-acetylpyrazine is a pyrazine that is substituted by an acetyl group at position 2. It has been identified as one of the volatile flavor constituents in popcorn, bread crust, vinegar, and potato snacks. It has a role as a flavouring agent. It is an aromatic ketone and a member of pyrazines.
2-Acetylpyrazine is a nitrogen containing compound that has been used in biological studies. 2-Acetylpyrazine has been shown to have inhibitory properties against the growth of prostate cancer cells and other cell lines. It also inhibits the production of fatty acids and epidermal growth factor, which are important for cellular proliferation. The inhibition is due to the photochemical properties of 2-acetylpyrazine, which cause the formation of reactive species that react with biological molecules. The reactive species may be generated by either a reaction mechanism or a reaction pathway that involve coordination geometry. 2-acetylpyrazine has also been used as a fluorescence probe for fatty acid detection in lipid bilayers and liposomes., Application In Synthesis of 22047-25-2