In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1082843-72-8 as follows. Quality Control of 6-Bromo-3-chloropyrazin-2-amine
General procedure: Sodium ethanethiolate (1.85 g, 21.95 mmol) was added to a solution of 4,6-dichloropyrimidin-5-amine (3.00 g, 18.29mmol) in methanol(100 mL) and heated at reflux for 3 hours. The reactionmixture was evaporated to dryness and redissolved in EtOAc (50 mL) and washed sequentially with water (50 mL) and saturated brine (50 mL). The organic phase was dried over MgSO4, filtered and evaporated toafford the crudeproduct. The crude product was purified by flash silica chromatography, elutiongradient 5% to 25% EtOAc in heptane. Pure fractions were evaporated to drynessto afford 4-chloro-6-(ethylthio)pyrimidin-5-amine (2.70 g, 78%) as a white solid;
According to the analysis of related databases, 1082843-72-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Boyd, Scott; Davies, Robert D.M.; Degorce, Sebastien L.; Groombridge, Sam; S. Scott, James; Stokes, Stephen; Tetrahedron Letters; vol. 57; 1; (2016); p. 152 – 154;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem