Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. 22047-25-2, formula is C6H6N2O, Name is Acetylpyrazine. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry.. Formula: C6H6N2O.
Basheer, Sabeel M.;Rasin, Puthiyavalappil;Ashok Kumar, Saravana Loganathan;Saravana Kumar, Moorthy;Sreekanth, Anandaram research published 《 Investigation on DNA/Protein interaction of thiosemicarbazone based octahedral nickel(II) and iron(III) complexes》, the research content is summarized as follows. 2-Acetylpyrazine N-(4)-cyclohexylthiosemicarbazide (H2L) and its metal complexes of Ni(II) and Fe(III) were synthesized. The structure of H2L and corresponding metal complexes are proposed based on the elemental anal., UV-Visible, FTIR spectroscopy, and Far IR. It is evident by single diffraction x-ray crystallog. that there is a distortion in the octahedral geometry owing to the two units of ligands surrounding the metal ion. To exploit the medicinal potential of the complex thus synthesized, their chem. interactions with Bovine Serum Albumin and CT-DNA were studied at normal physiol. conditions using UV-Visible, fluorescence spectral, and viscosity measurement techniques. The results obtained from these studies revealed that the complexes exhibit high affinity for DNA with an affinity constant of 106 M-1 and show noncovalent intercalation. The binding constant (Ka) was calculated by using UV-Visible titration from which it is inferred that Ni(II) has more affinity toward CT-DNA compared to Fe(III) complex. Also, it is established by that there were no extrinsic agents responsible for the DNA cleavage by the complexes. Also, absorption and fluorescent techniques were incorporated to study the interactivity of NiL2 and FeL2 with bovine serum albumin (BSA). In-silico methods were adapted to evaluate the DNA-complex interactions. The outcome of exptl. as well as in-silico studies suggests that the metal complexes intercalate with the CT-DNA mols.
22047-25-2, 2-Acetylpyrazine has been identified as one of the volatile flavor constituents in popcorn, wheat and rye bread crust.
2-Acetylpyrazine, also known as 1-pyrazinylethanone or fema 3126, belongs to the class of organic compounds known as aryl alkyl ketones. These are ketones have the generic structure RC(=O)R’, where R = aryl group and R’=alkyl group. 2-Acetylpyrazine exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 2-acetylpyrazine is primarily located in the cytoplasm. 2-Acetylpyrazine has a bitter, bread crust, and chip taste.
2-acetylpyrazine is a pyrazine that is substituted by an acetyl group at position 2. It has been identified as one of the volatile flavor constituents in popcorn, bread crust, vinegar, and potato snacks. It has a role as a flavouring agent. It is an aromatic ketone and a member of pyrazines.
2-Acetylpyrazine is a nitrogen containing compound that has been used in biological studies. 2-Acetylpyrazine has been shown to have inhibitory properties against the growth of prostate cancer cells and other cell lines. It also inhibits the production of fatty acids and epidermal growth factor, which are important for cellular proliferation. The inhibition is due to the photochemical properties of 2-acetylpyrazine, which cause the formation of reactive species that react with biological molecules. The reactive species may be generated by either a reaction mechanism or a reaction pathway that involve coordination geometry. 2-acetylpyrazine has also been used as a fluorescence probe for fatty acid detection in lipid bilayers and liposomes., Formula: C6H6N2O