Adding a certain compound to certain chemical reactions, such as: 54013-06-8, name is Ethyl 5-aminopyrazine-2-carboxylate, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54013-06-8, name: Ethyl 5-aminopyrazine-2-carboxylate
A mixture of aminopyrazine, 3-bromo-1,1,1-trifluoropropan-2-one and ethanol was heated in a microwave synthesizer at 180 C for 60 minutes. After cooling to room temperature, the solvent is removed and the dark brown residue is purified by flash chlromatography (silica, 30-60% ethyl acetate/hexanes) to give I-3 as a tan colored solid. 1H NMR (400 MHz, CDCI3) delta 9.24 (s, 1H), 8.99 (d, J= 1.4, 1H), 8.10 (s, 1H), 4.51 (q, J= 7.1, 2H), 1.46 (t, J= 7.1, 3H).
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Reference:
Patent; IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; LEONG, Seh Yong; ROLAND, Jason Thomas; MISHRA, Pranab Kumar; YEUNG, Bryan KS; ZOU, Bin; WO2014/78813; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem