Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Screening of strains for microbial transformation from DL-ATC to L-cysteine.Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.
Microorganisms for bioconversion from DL-2-amino-2,3-dihydrothiazole-4-carboxylic acid (DL-ATC) to L-cysteine were isolated from 20 soil samples with DL-ATC as sole N source for isolated plate. Five bacterial strains, GJx5, GJx7, TJ4, TJ6, and TJ7, were screened. Strain GJx7 was the most effective, with the productivity 68.3 μg/mL of L-cysteine. GJx7 was genetically stable; the relative activity for the 8th generation was 95.4%. The optimum conditions for enzyme production in strain GJx7 were as follows: the optimal pH for medium was 7.0, and the optimal loading amount was 50 mL for 250 mL shake flask. The optimal C source and N source were maltose and yeast extract, resp. The productivity of L-cysteine was 320.2 μg/mL under optimum conditions.
After consulting a lot of data, we found that this compound(2150-55-2)Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid can be used in many types of reactions. And in most cases, this compound has more advantages.